Resource: Animal Models

C9orf72 BAC-based transgenic mouse model: Target ALS has funded the development of a C9orf72 BAC-based transgenic mouse model in partnership with F-Prime Biomedical Research Initiative (FBRI) and The Jackson Laboratory (JAX).

The Jackson Laboratory in collaboration with Target ALS and FBRI will work to characterize this model and standardize use for in vivo target validation studies. This model with be distributed to the ALS research community by The Jackson Laboratory, and will also be available for efficacy studies through the Target ALS in vivo target validation core. We expect this model to be available by last quarter of 2019.

AAV-C9orf72-149 Repeat Expansion Mouse Model: We have in-licensed this model from Mayo Clinic. The Jackson Laboratory in collaboration with Target ALS is working to characterize this model and standardize use for in vivo target validation studies. We expect this model to be available by last quarter of 2019.

For more information on either mouse model contact Manish Raisinghani.